Dieter Riethmacher, PhD

Biography

Selected Publications

After finishing his Diploma in Biology at the University of Cologne, Germany, he did a PhD in the Max-Planck-Institute in Cologne. He then went to do a Post-doctoral in the Max-Delbrück Center for Molecular Medicine in Berlin, Germany, one of the finest institutes for medically relevant research in Germany. From there he moved on to his first independent position at the Center for Molecular Neurobiology (ZMNH) in Hamburg, Germany. His research there was mainly centered on the development and maintenance of the nervous system but he also led research on other topics like development of new tools for modelling disease in mice and cancer. In 2005 he habilitated in Neurobiology at the Medical Faculty of the University of Hamburg. He then accepted an offer to join the University of Southampton, UK, as an associate Professor. His projects there were a continuation of neuro-scientific research including regeneration but also expanded into other areas like immunology, lung and liver disease, cancer and sex determination. During all this time he attracted grant money and supervised and guided numerous PhD students and Post-doctorals. His over 40 peer reviewed articles have been published in high impact factor journals including Nature (5x), Cell (1x), Genes & Development (5x), Immunity (2x), Hepatology (2x), PNAS (4x) and Journal of experimental Medicine (2x). In Southampton besides teaching he was also managing the scientific projects of medical students. Since 2013 he was also involved in establishing the BMEU curriculum for medical students, a joint programme between the Medical Faculty of the University of Southampton and the Kassel School of Medicine (KSM).

1. Riethmacher, D., V. Brinkmann, and C. Birchmeier, 1995, A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development, Proc Natl Acad Sci U S A, 92(3), 855-9.

2. Riethmacher, D., E. Sonnenberg-Riethmacher, V. Brinkmann, T. Yamaai, G. R. Lewin, and C. Birchmeier, 1997, Severe neuropathies in mice with targeted mutations in the ErbB3 receptor, Nature, 389(6652), 725-30.

3. Britsch, S., L. Li, S. Kirchhoff, F. Theuring, V. Brinkmann, C. Birchmeier, and D. Riethmacher, 1998, The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system, Genes Dev, 12(12), 1825-36.

4. Stolt, C. C., S. Rehberg, M. Ader, P. Lommes, D. Riethmacher, M. Schachner, U. Bartsch, and M. Wegner, 2002, Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10, Genes Dev, 16(2), 165-70.

5. Brockschnieder, D., C. Lappe-Siefke, S. Goebbels, M. R. Boesl, K. A. Nave, and D. Riethmacher, 2004, Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination, Mol Cell Biol, 24(17), 7636-42.

6. Gosgnach, S., G. M. Lanuza, S. J. Butt, H. Saueressig, Y. Zhang, T. Velasquez, D. Riethmacher, E. M. Callaway, O. Kiehn, and M. Goulding, 2006, V1 spinal neurons regulate the speed of vertebrate locomotor outputs, Nature, 440(7081), 215-9.

7. Wetzel, C., J. Hu, D. Riethmacher, A. Benckendorff, L. Harder, A. Eilers, R. Moshourab, A. Kozlenkov, D. Labuz, O. Caspani, B. Erdmann, H. Machelska, P. A. Heppenstall, and G. R. Lewin, 2007, A stomatin-domain protein essential for touch sensation in the mouse, Nature, 445(7124), 206-9.

8. Birnberg, T., L. Bar-On, A. Sapoznikov, M. L. Caton, L. Cervantes-Barragan, D. Makia, R. Krauthgamer, O. Brenner, B. Ludewig, D. Brockschnieder, D. Riethmacher, B. Reizis, and S. Jung, 2008, Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome, Immunity 29(6), p. 986-997.

9. Beraza, N., Y. Malato, L. E. Sander, M. Al-Masaoudi, J. Freimuth, D. Riethmacher, G. J. Gores, T. Roskams, C. Liedtke, and C. Trautwein, 2009, Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage, J Exp Med, 206(8), 1727-37.

10. Malin, D., E. Sonnenberg-Riethmacher, D. Guseva, R. Wagener, A. Aszodi, A. Irintchev, and D. Riethmacher, 2009, The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration, J Cell Sci, 122(Pt 7), 995-1004.

11. Uhlenhaut, N. H., S. Jakob, K. Anlag, T. Eisenberger, R. Sekido, J. Kress, A. C. Treier, C. Klugmann, C. Klasen, N. I. Holter, D. Riethmacher, G. Schutz, A. J. Cooney, R. Lovell-Badge, and M. Treier, 2009, Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation, Cell, 139(6), 1130-42.

12. Yogev, N., F. Frommer, D. Lukas, K. Kautz-Neu, K. Karram, D. Ielo, E. von Stebut, H. C. Probst, M. van den Broek, D. Riethmacher, T. Birnberg, T. Blank, B. Reizis, T. Korn, H. Wiendl, S. Jung, M. Prinz, F. C. Kurschus, and A. Waisman, 2012, Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor(+) Regulatory T Cells. Immunity, 2012. 37(2), 264-275.

13. Sonnenberg-Riethmacher, E., Miehe, M. and Riethmacher, D. (2015). Promotion of periostin expression contributes to the migration of Schwann cells. J Cell Sci, 128, 3345-55.

14. Dahlhoff, M., Camera, E., Schäfer, M., Emrich, D., Riethmacher, D., Foster, A., Paus, R. & Schneider, M. R., 2016, Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Development. 143 (10) p. 1823-31.
15. De Frutos, C. A., Bouvier, G., Arai, Y., Thion, M. S., Lokmane, L., Keita, M., Garcia-Dominguez, M., Charnay, P., Hirata, T., Riethmacher, D., Grove, E. A., Tissir, F., Casado, M., Pierani, A. & Garel, S., 2016, Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture. Neuron. 92 (2), p. 435-448.

16. Yamazaki S, Odanaka M, Nishioka A, Kasuya S, Shime H, Hemmi H, Imai M, Riethmacher D, Kaisho T, Ohkura N, Sakaguchi S, Morita A. (2018). Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin. J Immunol. 2018 Jan 1;200(1):119-129.

17. Tanoue T., Morita S., Plichta8 D.R., Skelly A.N., Suda W., Narushima S., Sugiura Y., Vlamakis H., Motoo I., Sugita K., Shiota A., Takeshita K., Yasuma K., Riethmacher D., Kaisho T., Norman J.M., Mucida D., Suematsu M., Yaguchi T., Bucci V., Inoue T., Kawakami Y., Olle B., Roberts B., Hattori M., Xavier R.J., Atarashi K., Honda K. (2019).A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature 2019 Jan;565(7741):600-605.

School of Medicine

Faculty and Research

Research Interest

School of Medicine