Antanas Gulbinas has completed his MD degree in Kaunas University of Medicine, Lithuania. The studies were followed by the residency and licenses of Abdominal Surgeon in Lithuania. From 1999 to 2003 he was a PhD student at Kaunas University of Medicine. In 2004, Antanas Gulbinas completed PhD thesis on “Risk factors and prognostification of the complications related to the pancreatojejunal anastomosis insufficiency after pancreatoduodenectomy.
During 2002‐2003, he was appointed as a researcher in European Pancreas Research Laboratory, Heidelberg University, Germany, where he investigated the role of transcription factor GATA‐3 in pathogenesis of pancreatic cancer. Before joining the School of Medicine of Nazarbayev University he has been working as a surgeon, professor and chief researcher in Lithuanian University of Health Sciences. Antanas Gulbinas was leading the Surgical Gastroenterology Research Lab at the Institute of Digestive research, Lithuanian University of Health Sciences.
His main research areas: diagnostics, prognosis and pathogenesis of the inflammatory and neoplastic pancreatic diseases. Recent projects focus on the role of mRNA stabilizing proteins, HSP’s and other cytoprotective molecules in the pathogenesis and course of pancreatic cancer. Studies combine both use of clinical data, tissue samples from patients and in vitro studies with pancreatic cancer cell lines. He introduced the techniques for isolation and cell culture of human pancreatic stellate cells in the Surgical Gastroenterology Research Lab.

Antanas Gulbinas is a Council member of the European Digestive Surgery (EDS), member of International Hepato-Pancreato-Biliary Association (IHPBA), Board of Lithuanian Association of Surgeons and the Research Board of United European Gastroenterology

1. Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z. Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer. World J Gastroenterol. 2019 Jan 14;25(2):205-219.
2. Bieliuniene E, Frøkjær JB, Pockevicius A, Kemesiene J, Lukosevicius S, Basevicius A, Barauskas G, Dambrauskas Z, Gulbinas A. Magnetic Resonance Imaging as a Valid Noninvasive Tool for the Assessment of Pancreatic Fibrosis. Pancreas. 2019 Jan;48(1):85-93.
3. Schreuder AM, Busch OR, Besselink MG, Ignatavicius P, Gulbinas A, Barauskas G, Gouma DJ, van Gulik TM. Long-Term Impact of Iatrogenic Bile Duct Injury. Dig Surg. 2019 Jan 17:1-12.
4. Vizbaras A, Šimonytė I, Miasojedovas A, Trinkūnas A, Bučiūnas T, Greibus M, Naujokaitė G, Torcheboeuf N, Droz S, Boiko D, Dambrauskas Ž, Gulbinas A, Vizbaras K. Swept-wavelength lasers based on GaSb gain-chip technology for non-invasive biomedical sensing applications in the 1.7-2.5 μm wavelength range. Biomed Opt Express. 2018 Sep 14;9(10):4834-4849.
5. Eismontas V, Slepavicius A, Janusonis V, Zeromskas P, Beisa V, Strupas K, Dambrauskas Z, Gulbinas A, Martinkenas A. Predictors of postoperative hypocalcemia occurring after a total thyroidectomy: results of prospective multicenter study. BMC Surg. 2018 Aug 9;18(1):55.
6. Trumbeckaite S, Cesna V, Jasukaitiene A, Baniene R, Gulbinas A. Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines. J Bioenerg Biomembr. 2018 Oct;50(5):329-338.
7. Cesna V, Sukovas A, Jasukaitiene A, Naginiene R, Barauskas G, Dambrauskas Z, Paskauskas S, Gulbinas A. Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells. World J Gastroenterol. 2018 Mar 14;24(10):1072-1083.
8. GlobalSurg Collaborative. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis. 2018 May;18(5):516-525.
9. Sukovas A, Cesna V, Jasukaitiene A, Barauskas G, Nadisauskiene RJ, Dambrauskas Z, Paskauskas S, Gulbinas A. Response of OVCAR-3 Cells to Cisplatin and Hyperthermia: Does Hyperthermia Really Matter? Anticancer Res. 2017 Sep;37(9):5011-5018.
10. Olesen SS, Poulsen JL, Drewes AM, Frøkjær JB, Laukkarinen J, Parhiala M, Rix I, Novovic S, Lindkvist B, Bexander L, Dimcevski G, Engjom T, Erchinger F, Haldorsen IS, Pukitis A, Ozola-Zālīte I, Haas S, Vujasinovic M, Löhr JM, Gulbinas A, Jensen NM, Jørgensen MT, Nøjgaard C; Scandinavian Baltic Pancreatic Club (SBPC). The Scandinavian baltic pancreatic club (SBPC) database: design, rationale and characterisation of the study cohort. Scand J Gastroenterol. 2017 Aug;52(8):909-915
11. Žūkienė R, Naučienė Z, Šilkūnienė G, Vanagas T, Gulbinas A, Zimkus A, Mildažienė V. Contribution of mitochondria to injury of hepatocytes and liver tissue by hyperthermia. Medicina (Kaunas). 2017;53(1):40-49.
12. Barauskas G, Urbonas K, Smailyte G, Pranys D, Pundzius J, Gulbinas A. Preoperative Endoscopic Biliary Drainage May Negatively Impact Survival Following Pancreatoduodenectomy for Ampullary Cancer. Dig Surg. 2016;33(6):462-9.
13. Kuliaviene I, Baniene R, Virketyte S, Kincius M, Jansen E, Gulbinas A, Kupcinskas L, Trumbeckaite S, Borutaite V. Methylene blue attenuates mitochondrial dysfunction of rat kidney during experimental acute pancreatitis. J Dig Dis. 2016 Mar;17(3):186-92.
14. Jakstaite A, Maziukiene A, Silkuniene G, Kmieliute K, Dauksa A, Paskauskas S, Gulbinas A, Dambrauskas Z. Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy. Langenbecks Arch Surg. 2016 Feb;401(1):99-111.
15. Jakstaite A, Maziukiene A, Silkuniene G, Kmieliute K, Gulbinas A, Dambrauskas Z. HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer. World J Gastroenterol. 2015 Dec 14;21(46):13004-19.
16. Cesna V, Baniene R, Maziukiene A, Kmieliute K, Trumbeckaite S, Venclauskas L, Barauskas G, Gulbinas A. Effects of Cyanidin-3-O-glucoside on Synthetic and Metabolic Activity of Ethanol Stimulated Human Pancreatic Stellate Cells. Phytother Res. 2015 Dec;29(12):1894-900.
17. Nüsgen N, Goering W, Dauksa A, Biswas A, Jamil MA, Dimitriou I, Sharma A, Singer H, Fimmers R, Fröhlich H, Oldenburg J, Gulbinas A, Schulz WA, El-Maarri O. Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs. Clin Epigenetics. 2015 Mar 1;7:17.
18. Urbonas K, Gulbinas A, Smailyte G, Pranys D, Jakstaite A, Pundzius J, Barauskas G. Factors influencing survival after pancreatoduodenectomy for ductal adenocarcinoma depend on patients’ age. Dig Surg. 2015;32(1):60-7.
19. Petraitienė I, Barauskas G, Gulbinas A, Malcius D, Hussain K, Verkauskas G, Verkauskienė R. Congenital hyperinsulinism. Medicina (Kaunas). 2014;50(3):190-5.
20. Dauksa A, Gulbinas A, Endzinas Z, Oldenburg J, El-Maarri O. DNA methylation at selected CpG sites in peripheral blood leukocytes is predictive of gastric cancer. Anticancer Res. 2014 Oct;34(10):5381-8.
21. Gulla A, Evans BJ, Navenot JM, Pundzius J, Barauskas G, Gulbinas A, Dambrauskas Z, Arafat H, Wang ZX. Heme oxygenase-1 gene promoter polymorphism is associated with the development of necrotizing acute pancreatitis. Pancreas. 2014 Nov;43(8):1271-6.
22. Kuliaviene I, Gulbinas A, Cremers J, Pundzius J, Kupcinskas L, Dambrauskas Z, Jansen E. Fatty acids of erythrocyte membrane in acute pancreatitis patients. World J Gastroenterol. 2013 Sep 14;19(34):5678-84.
23. Trumbeckaite S, Kuliaviene I, Deduchovas O, Kincius M, Baniene R, Virketyte S, Bukauskas D, Jansen E, Kupčinskas L, Borutaite V, Gulbinas A. Experimental acute pancreatitis induces mitochondrial dysfunction in rat pancreas, kidney and lungs but not in liver. Pancreatology. 2013 May-Jun;13(3):216-24.
24. Dauksa A, Gulbinas A, Barauskas G, Pundzius J, Oldenburg J, El-Maarri O. Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study. PLoS One. 2012;7(5):e37509.
25. Barauskas G, Paškauskas S, Dambrauskas Z, Gulbinas A, Pundzius J. Referral pattern, management, and long-term results of laparoscopic bile duct injuries: a case series of 44 patients. Medicina (Kaunas). 2012;48(3):138-44.
26. Dambrauskas Z, Parseliūnas A, Maleckas A, Gulbinas A, Barauskas G, Pundzius J. Interventional and surgical management of abdominal compartment syndrome in severe acute pancreatitis. Medicina (Kaunas). 2010;46(4):249-55.
27. Vanagas T, Gulbinas A, Pundzius J, Barauskas G. Radiofrequency ablation of liver tumors (II): clinical application and outcomes. Medicina (Kaunas). 2010;46(2):81-8. Review.
28. Dambrauskas Z, Giese N, Gulbinas A, Giese T, Berberat PO, Pundzius J, Barauskas G, Friess H. Different profiles of cytokine expression during mild and severe acute pancreatitis. World J Gastroenterol. 2010 Apr 21;16(15):1845-53.
29. Dambrauskas Z, Gulbinas A, Pundzius J, Barauskas G. Value of the different prognostic systems and biological markers for predicting severity and progression of acute pancreatitis. Scand J Gastroenterol. 2010 Aug;45(7-8):959-70.
30. Vanagas T, Gulbinas A, Pundzius J, Barauskas G. Radiofrequency ablation of liver tumors (I): biological background. Medicina (Kaunas). 2010;46(1):13-7. Review.
31. Gelmanas A, Pundzius J, Gulbinas A, Smailys A, Macas A. [Pattern and causes of hemodynamic changes during hepatic resection]. Medicina (Kaunas). 2010;46(11):760-6. Lithuanian.
32. Trumbeckaite S, Kincius M, Preidis A, Preidiene M, Veikutis V, Borutaite V, Gulbinas A. Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function. Pharmacol Rep. 2009 Sep-Oct;61(5):859-69.
33. Vanagas T, Gulbinas A, Sadauskiene I, Dambrauskas Z, Pundzius J, Barauskas G. Apoptosis is activated in an early period after radiofrequency ablation of liver tissue. Hepatogastroenterology. 2009 Jul-Aug;56(93):1095-9.
34. Dambrauskas Z, Parseliunas A, Gulbinas A, Pundzius J, Barauskas G. Early recognition of abdominal compartment syndrome in patients with acute pancreatitis. World J Gastroenterol. 2009 Feb 14;15(6):717-21.
35. Grizas S, Gulbinas A, Barauskas G, Pundzius J. A comparison of the effectiveness of the early enteral and natural nutrition after pancreatoduodenectomy. Medicina (Kaunas). 2008;44(9):678-86.
36. Barauskas G, Gulbinas A, Pranys D, Dambrauskas Z, Pundzius J. Tumor-related factors and patient’s age influence survival after resection for ampullary adenocarcinoma. J Hepatobiliary Pancreat Surg. 2008;15(4):423-8.
37. Barauskas R, Gulbinas A, Vanagas T, Barauskas G. Finite element modeling of cooled-tip probe radiofrequency ablation processes in liver tissue. Comput Biol Med. 2008 Jun;38(6):694-708.
38. Berberat PO, Künzli BM, Gulbinas A, Ramanauskas T, Kleeff J, Müller MW, Wagner M, Friess H, Büchler MW. An audit of outcomes of a series of periampullary carcinomas. Eur J Surg Oncol. 2009 Feb;35(2):187-91.
39. Dambrauskas Z, Gulbinas A, Pundzius J, Barauskas G. Value of routine clinical tests in predicting the development of infected pancreatic necrosis in severe acute pancreatitis. Scand J Gastroenterol. 2007 Oct;42(10):1256-64.
40. Barauskas G, Gulbinas A, Pundzius J. Results of surgical treatment of carcinoma of papilla of Vater. Medicina (Kaunas). 2007;43(6):455-62.
41. Barauskas R, Gulbinas A, Barauskas G. Finite element modeling and experimental investigation of infiltration of sodium chloride solution into nonviable liver tissue. Medicina (Kaunas). 2007;43(5):399-411.
42. Barauskas R, Gulbinas A, Barauskas G. Investigation of radiofrequency ablation process in liver tissue by finite element modeling and experiment. Medicina (Kaunas). 2007;43(4):310-25.
43. Dambrauskas Z, Gulbinas A, Pundzius J, Barauskas G. Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis. Medicina (Kaunas). 2007;43(4):291-300. Review.
44. Berberat PO, Ingold H, Gulbinas A, Kleeff J, Müller MW, Gutt C, Weigand M, Friess H, Büchler MW. Fast track–different implications in pancreatic surgery. J Gastrointest Surg. 2007 Jul;11(7):880-7.
45. Gulbinas A, Berberat PO, Dambrauskas Z, Giese T, Giese N, Autschbach F, Kleeff J, Meuer S, Büchler MW, Friess H. Aberrant gata-3 expression in human pancreatic cancer. J Histochem Cytochem. 2006 Feb;54(2):161-9. Epub 2005 Aug 8.
46. Berberat PO, Dambrauskas Z, Gulbinas A, Giese T, Giese N, Künzli B, Autschbach F, Meuer S, Büchler MW, Friess H. Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment. Clin Cancer Res. 2005 May 15;11(10):3790-8.
47. Gulbinas A, Barauskas G, Pundzius J. [Pancreaticojejunal anastomosis: the “Achilles heel” of pancreaticoduodenectomy]. Medicina (Kaunas). 2004;40(10):927-34. Review. Lithuanian.
48. Gulbinas A, Barauskas G, Pundzius J. Preoperative stratification of pancreas-related morbidity after the Whipple procedure. Int Surg. 2004 Jan-Mar;89(1):39-45.
49. Bornman PC, Marks IN, Girdwood AW, Berberat PO, Gulbinas A, Büchler MW. Pathogenesis of pain in chronic pancreatitis: ongoing enigma. World J Surg. 2003 Nov;27(11):1175-82.
50. Barauskas G, Gulbinas A, Pundzius J. [Influence of preoperative biliary drainage and obstructive jaundice on the early outcome of pancreaticoduodenectomy]. Medicina (Kaunas). 2003;39(4):359-64. Lithuanian.
51. Gulbinas A, Barauskas G, Pundzius J, Pranys D. [The impact of morphologic and physiologic peculiarities of the pancreas on pancreas-related complications following pancreatoduodenectomy]. Medicina (Kaunas). 2003;39(2):151-7. Lithuanian.